www射-国产免费一级-欧美福利-亚洲成人福利-成人一区在线观看-亚州成人

Global EditionASIA 中文雙語Fran?ais
China
Home / China / Innovation

Chinese scientists reveal why Zika virus causes microcephaly

Xinhua | Updated: 2017-09-29 09:29
Share
Share - WeChat

 

Luiz Philipe, who was born with microcephaly, sleeps in his house in Marica, Rio de Janeiro state, Brazil, on March 9, 2016. Brazil will adopt the World Health Organization (WHO) standards from the next week to determine if a baby has microcephaly, the Brazilian Health Ministry said on Wednesday. [Photo/Xinhua]


WASHINGTON -- Chinese researchers said Thursday they might have solved the mystery of why the Zika virus causes microcephaly, a birth defect marked by small head size that can lead to severe developmental problems in babies.

In a study published in the US journal Science, a team led by Cheng-Feng Qin of the Beijing Institute of Microbiology and Epidemiology reported that one single genetic change, likely acquired in 2013, gave the mosquito-borne virus the ability to cause severe fetal microcephaly.

"Our findings offer a reasonable explanation for the unexpected causal link of Zika to microcephaly, and will help understand how Zika evolved from an innocuous mosquito-borne virus into a congenital pathogen with global impact," Qin said.

Zika was first identified in 1947 in Uganda, and until its recent emergence in the Americas, was a little known one that sporadically causes mild infections.

Then, it rapidly swept through South and Central America in 2015, and due to its link to congenital brain abnormalities, especially microcephaly during pregnancy, the World Health Organization declared in early 2016 the current epidemics a public health emergency of international concern.

However, scientists remain unable to determine why the virus evolved into a pathogen triggering severe neurological syndromes.

By comparing contemporary Zika virus strains from the 2015 and 2016 South American epidemics with an ancestral Cambodian virus that was circulating in 2010, Qin and colleagues found one critical mutation that conferred the ability to cause microcephaly in mouse models of fetal infection.

That one change, S139N, which replaced a serine amino acid with an asparagine at the 139th position of a Zika protein called prM, also made the virus more lethal to human neuron precursor cells in culture compared with the ancestral form.

Zika accumulated numerous changes throughout its genome between 2010 and 2016, of which S139N caused substantially more severe microcephaly and embryonic lethality in mouse models.

Evolutionary analyses revealed that the S139N change likely arose sometime around 2013, which coincided with initial reports of microcephaly.

It was then stably maintained during subsequent spread to the America.

"The discovery should provide guidance for the study of pathogenetic mechanisms of the Zika virus and for the development of vaccines and treatments," Qin said.

 

Top
BACK TO THE TOP
English
Copyright 1995 - . All rights reserved. The content (including but not limited to text, photo, multimedia information, etc) published in this site belongs to China Daily Information Co (CDIC). Without written authorization from CDIC, such content shall not be republished or used in any form. Note: Browsers with 1024*768 or higher resolution are suggested for this site.
License for publishing multimedia online 0108263

Registration Number: 130349
FOLLOW US
 
主站蜘蛛池模板: 一级毛片免费不卡在线视频 | 中文字幕一二三四区2021 | 久久99毛片免费观看不卡 | 免费观看欧美精品成人毛片 | 国产精品路边足疗店按摩 | 国产高清在线不卡 | 99国产精品久久久久久久成人热 | 精品72久久久久久久中文字幕 | 一级视频在线观看 | 日本亚州视频在线八a | 国产日本三级 | 精品 日韩 国产 欧美在线观看 | 俄罗斯黄色毛片 | 美女脱了内裤张开腿让男人桶网站 | 在线中文字幕视频 | 久久久免费视频观看 | 国产一区二区三区久久小说 | 高清欧美日本视频免费观看 | 国产欧美日韩在线观看精品 | 色涩五月天 | www.av在线视频 | 欧美一级毛片欧美一级 | 亚洲精品久久久午夜伊人 | 毛片视频网站在线观看 | 91久久香蕉国产线看观看软件 | 国产dvd毛片在线视频 | 色秀视频在线观看88品善网 | 国产aaaaa一级毛片 | 996热在线视频 | 中国性猛交xxxxx免费看 | 手机免费毛片 | 欧美日韩国产综合一区二区三区 | 杨幂国产精品福利在线观看 | 成人小视频在线播放 | 神马午夜-午夜片 | 老司机午夜在线视频免费观 | 自拍一页 | 国产成人亚洲合集青青草原精品 | 91精品国产一区二区三区左线 | 国产亚洲高清视频 | 看全色黄大色黄大片毛片 |